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Benedict Cumberbatch Grinch (voice) Rashida Jones Donna Lou Who (voice) Kenan Thompson Bricklebaum (voice) Cameron Seely Cindy Lou Who (voice) Angela Lansbury Mayor McGerkle (voice) Pharrell Williams Narrator (voice) Ramone Hamilton Axl (voice) Sam Lavagnino Ozzy (voice) Scarlett Estevez Izzy (voice) Michael Beattie Store Clerk (voice) Scott Mosier Additional Voices (voice) Lori Alan Additional Voices (voice) Carter Hastings Additional Voices (voice) Carlos Alazraqui Additional Voices (voice) John Kassir Additional Voices (voice) Cathy Cavadini Additional Voices (voice) Danny Mann Additional Voices (voice) Meilee Condron Additional Voices (Voice) Tristan O'Hare Groopert (voice) Doug Burch Additional Voices (voice) Tucker Chandler Additional Voices (voice) Townsend Coleman Additional Voices (voice) Abby Craden Additional Voices (voice) Brian T. Delaney Additional Voices (voice) John DeMita Additional Voices (voice) Bill Farmer Additional Voices (voice) Aaron Fors Additional Voices (voice) Willow Geer Additional Voices (voice) Jess Harnell Additional Voices (voice) Evan Kishiyama Additional Voices (voice) Barbara Harris Additional Voices (voice) Jeremy Maxwell Additional Voices (voice) Laraine Newman Additional Voices (voice) Dashiell Priestley Additional Voices (voice) Alex Puccinelli Additional Voices (voice) Emma Elizabeth Shannon Additional Voices (voice) Joel Swetow Additional Voices (voice) Mindy Sterling Additional Voices (voice) Tara Strong Additional Voices (voice) Regina Taufen Additional Voices (voice) Jim Ward Additional Voices (voice)