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Whoopi Goldberg Ranger Margaret (voice) David Spade Ranger Frank (voice) E. G. Daily Tommy Pickles (voice) Tara Strong Dilan "Dil" Pickles (voice) Christine Cavanaugh Chuckie Finster (voice) Kath Soucie Phil / Lil / Betty DeVille (voices) Cheryl Chase Angelica Pickles (voice) Tim Curry Rex Pester (voice) Jack Riley Stuart 'Stu' Pickles (voice) Busta Rhymes Reptar Wagon (voice) Michael Bell Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice) Joe Alaskey Grandpa Lou Pickles (voice) Phil Proctor Howard DeVille / Igor (voice) Cree Summer Susie Carmichael (voice) Tress MacNeille Charlotte Pickles (voice) Melanie Chartoff Didi Pickles / Minka Kropotkin (voice) Hattie Winston Lucy Carmichael (voice) Andrea Martin Aunt Miriam (voice) Tony Jay Dr. Lipschitz (voice) Abraham Benrubi Serge (voice) Gregg Berger TV Announcer (voice) Charlie Adler United Express Driver (voice) Mary Gross Female Guest (voice) Edie McClurg Nurse (voice) Roger Clinton Jr. Air Crewman (voice) Margaret Cho Lt. Klavin (voice) Iggy Pop Newborn Baby (singing voice) Louis Fresse Newborn Baby (singing voice) Lisa Loeb Newborn Baby (singing voice) Lenny Kravitz Newborn Baby (singing voice) Dawn Robinson Newborn Baby (singing voice) Lou Rawls Newborn Baby (singing voice) Kate Pierson Newborn Baby (singing voice) Cindy Wilson Newborn Baby (singing voice) Gordon Gano Newborn Baby (singing voice) Laurie Anderson Newborn Baby (singing voice) Malik Isaac Taylor Newborn Baby (singing voice) Fred Schneider Newborn Baby (singing voice) Jakob Dylan Newborn Baby (singing voice) Patti Smith Newborn Baby (singing voice) Beck Newborn Baby (singing voice) Steve Zirnkilton Reporter (voice) Frank Welker Spike / Monkeys / Scar Snout (voice) (uncredited) Phife Dawg Newborn Baby (Singing Voice)